Cheap flights from Guayaquil to Panama City from R2 691

The month of May is, on average, the cheapest month to fly to Panama City from Guayaquil, with most prices found around R4 560. If you aren’t able to travel during the month of May, then book flights to Panama City from Guayaquil during April instead. Flights to Panama City in April, while not as cheap as those in May, still average around R4 979.

You are more likely to see cheaper flights to Panama City from Guayaquil when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around R5 418 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Guayaquil for as low as R5 140 on momondo.

Historically, on average around 3% of flights between Guayaquil and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 102 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights departing in the early afternoon have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week that experiences the fewest delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the fewest delays on this route over the last 12 months, with about 3% of their flights experiencing any sort of delay.

As of September 2026, 13 flights take off from Guayaquil and land in Panama City each day. The most common flight departure time for this route is 14:00, with 50% of daily flights taking off in the afternoon.

The number of flights available between Guayaquil and Panama City is 97 per week as of September 2026. The most frequent departure day is Tue, with 15% of weekly flights leaving on this day.