Cheap flights from Panama City to Guayaquil from R3 879

In general, February is the cheapest month to fly from Panama City to Guayaquil. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around R5 044. If you don’t want to visit Guayaquil in February, then you should wait until December to fly from Panama City, when ticket prices are also cheap, with an average price of R5 776.

You are more likely to see cheaper flights to Guayaquil from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Guayaquil for around R6 281 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Guayaquil from Panama City for as low as R4 062 on momondo.

Historically, on average around 7% of flights between Panama City and Guayaquil have experienced a delay on any given week. The average delay length over the past 12 months has been 101 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights departing at night have, in the past, seen delays more frequently in comparison.

Wednesday is statistically the day of the week that experiences the fewest delays on this flight route. Monday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the fewest delays on this route over the last 12 months, with about 7% of their flights experiencing any sort of delay.

As of October 2026, there are 6 flights per day flying from Panama City to Guayaquil. The most common time of day flights depart is 21:00, with 86% of flights taking off in the evening.

As of October 2026, there are 45 flights per week flying from Panama City to Guayaquil. The most common day of the week flights depart is Wed, with 31% of flights taking off on this day.