Cheap flights from Santiago to Antofagasta from R509

In general, October is the cheapest month to fly from Santiago to Antofagasta. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around R1 247. If you aren’t able to travel during the month of October, then book flights to Antofagasta from Santiago during August instead. Flights to Antofagasta in August, while not as cheap as those in October, still average around R1 329.

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You are more likely to see cheaper flights to Antofagasta from Santiago when booking weeks ahead of your departure date. In general, you can expect to find flights to Antofagasta for around R1 528 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Antofagasta from Santiago for as low as R968 on momondo.

There is only 1 cabin class available to choose from on Santiago to Antofagasta flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Historically, on average around 8% of flights between Santiago and Antofagasta have experienced a delay on any given week. The average delay length over the past 12 months has been 93 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights departing in the evening have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week that experiences the fewest delays on this flight route. Friday has historically seen more delays on average compared to the rest of the week.

According to our data, LATAM Airlines have had the fewest delays on this route over the last 12 months, with about 7% of their flights experiencing any sort of delay.

As of September 2026, there are 4 flights per day flying from Santiago to Antofagasta. The most common time of day flights depart is 6:00, with 60% of flights taking off at midday.

33 flights are operational weekly from Santiago to Antofagasta as of September 2026. The most popular departure day for this route is Wed, with 91% of flights per week taking off on this day.