Cheap flights from Santo Domingo to Panama City from R5 555

The month of January is, on average, the cheapest month to fly to Panama City from Santo Domingo, with most prices found around R8 637. If you aren’t able to travel during the month of January, then book flights to Panama City from Santo Domingo during February instead. Flights to Panama City in February, while not as cheap as those in January, still average around R8 654.

You are more likely to see cheaper flights to Panama City from Santo Domingo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around R9 460 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Santo Domingo for as low as R8 769 on momondo.

Historically, on average around 5% of flights between Santo Domingo and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 109 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights departing in the early afternoon have, in the past, seen delays more frequently in comparison.

Saturday is statistically the day of the week that experiences the fewest delays on this flight route. Thursday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the fewest delays on this route over the last 12 months, with about 5% of their flights experiencing any sort of delay.

The number of flights available between Santo Domingo and Panama City is 8 per day as of November 2026. The most frequent departure time is 19:00, with 49% of daily flights leaving in the afternoon.

59 flights are operational weekly from Santo Domingo to Panama City as of November 2026. The most popular departure day for this route is Tue, with 17% of flights per week taking off on this day.