Cheap flights from Guatemala City to Panama City from R4 749

The month of February is, on average, the cheapest month to fly to Panama City from Guatemala City, with most prices found around R4 649. If you aren’t able to travel during the month of February, then book flights to Panama City from Guatemala City during April instead. Flights to Panama City in April, while not as cheap as those in February, still average around R4 665.

You are more likely to see cheaper flights to Panama City from Guatemala City when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around R5 368 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Guatemala City for as low as R5 032 on momondo.

Historically, on average around 3% of flights between Guatemala City and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 124 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights departing in the evening have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week that experiences the fewest delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the fewest delays on this route over the last 12 months, with about 3% of their flights experiencing any sort of delay.

As of October 2026, there are 10 flights per day flying from Guatemala City to Panama City. The most common time of day flights depart is 12:00, with 47% of flights taking off in the afternoon.

The number of flights available between Guatemala City and Panama City is 74 per week as of October 2026. The most frequent departure day is Thu, with 27% of weekly flights leaving on this day.