Cheap flights from Guatemala City to Panama City from R2 525

The month of November is, on average, the cheapest month to fly to Panama City from Guatemala City, with most prices found around R4 544. If you aren’t able to travel during the month of November, then book flights to Panama City from Guatemala City during October instead. Flights to Panama City in October, while not as cheap as those in November, still average around R4 577.

You are more likely to see cheaper flights to Panama City from Guatemala City when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City for around R5 006 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City from Guatemala City for as low as R4 610 on momondo.

Historically, on average around 3% of flights between Guatemala City and Panama City have experienced a delay on any given week. The average delay length over the past 12 months has been 124 minutes.

Generally, flights departing at night tend to experience fewer delays. Flights departing in the evening have, in the past, seen delays more frequently in comparison.

Monday is statistically the day of the week that experiences the fewest delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the fewest delays on this route over the last 12 months, with about 3% of their flights experiencing any sort of delay.

As of September 2026, there are 18 flights per day flying from Guatemala City to Panama City. The most common time of day flights depart is 12:00, with 55% of flights taking off in the afternoon.

The number of flights available between Guatemala City and Panama City is 129 per week as of September 2026. The most frequent departure day is Wed, with 15% of weekly flights leaving on this day.