Cheap flights from Panama City to Mexico City from R4 500

The cheapest month to fly to Mexico City from Panama City is in December. Flight prices, which tend to average around R5 540, are often lower during this time because this is during the off-season. If you don’t want to visit Mexico City in December, then you should wait until January to fly from Panama City, when ticket prices are also cheap, with an average price of R5 719.

You are more likely to see cheaper flights to Mexico City from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Mexico City for around R6 587 when searching weeks before you fly. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Mexico City from Panama City for as low as R5 768 on momondo.

Historically, on average around 4% of flights between Panama City and Mexico City have experienced a delay on any given week. The average delay length over the past 12 months has been 124 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights departing in the early afternoon have, in the past, seen delays more frequently in comparison.

Thursday is statistically the day of the week that experiences the fewest delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Copa Airlines have had the fewest delays on this route over the last 12 months, with about 3% of their flights experiencing any sort of delay.

As of September 2026, there are 8 flights per day flying from Panama City to Mexico City. The most common time of day flights depart is 9:00, with 46% of flights taking off at midday.

56 flights are operational weekly from Panama City to Mexico City as of September 2026. The most popular departure day for this route is Fri, with 16% of flights per week taking off on this day.